International Research Journal of Oncology <p style="text-align: justify;"><strong>International Research Journal of Oncology</strong>&nbsp;aims to publish case reports related to all aspects of oncology.&nbsp;The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.&nbsp;</p> International Research Journal of Oncology en-US International Research Journal of Oncology Inguinal Lymphadenopathy in Carcinoma Gall Bladder: An Unusual Site of Metastasis <p>Gall bladder cancer carries a dismal prognosis especially in advanced cases. Common sites of metastases include liver, lung and unusual sites have also been reported like orbit, cutaneous, adrenal, kidney, breast and thyroid. 66 years female diagnosed case of metastatic carcinoma gall bladder presented with bilateral inguinal lymphadenopathy. Cytology aspirate from inguinal node reported metastatic adenocarcinoma. Inguinal node metastases from gall bladder cancer is very rare and few case reports have been published. We present a case of a woman with advanced cancer of the gall bladder, who presented with bilateral inguinal metastases.</p> Ajas Ibrahim Debanjan Sikdar Sagar N Raut Jaydeep Jain Sweety Gupta Amit Gupta Prashant Joshi Manoj Gupta ##submission.copyrightStatement## 2020-01-23 2020-01-23 1 4 Implications of Molecular Estimation of Allelic Burden of JAK2 V617F Mutant Allele in Essential Thrombocythemia and Polycythemia Vera Diseases <p><strong>Aims: </strong>Development of a JAK2 Allelic burden estimation kit using Taqman probes and determine trend in shifting of <em>JAK2 V617F</em> allelic burden in and its use in analysis of patients with essential thrombocythemia (ET) and polycythemia vera (PV) to predict thrombotic complications.</p> <p><strong>Methodology: </strong>Through a retrospect study, a total of 412 ET and PV patient, divided into 3 groups (0-2, 2-5 and 5-10 years) based on time of detection of the disease, were tested in retrospect for presence of the <em>JAK2 V617F</em> mutant allele burden using an in-house developed Taqman probe-based kit, trend in shifting of the mutant allele burden was studied&nbsp; and segregated into ET (n=167) and PV (n=126) group based on their disease profile. It was then categorized into 3 time periods (0-2, 2-5 and 5-10 years) based on time of detection of the disease.&nbsp;</p> <p><strong>Results</strong><strong>:</strong> Around 293 (71%) were positive for <em>JAK2 V617F</em> while 59 (14.2%) and 8 (1.9%) positive for CALR exon 9 frame shift &amp; MPL mutations (W515L/W515K) respectively. The 1-25% allelic burden group size gradually fell in ET population over time and this trend continued in the PV population also.&nbsp; In the former the fall was 7% &amp; 11% for 2-5 &amp; 5-10 years category while in the later, it was 1% and 15% respectively for the same time period-category.&nbsp;</p> <p><strong>Conclusions: </strong>There is a distinct molecular continuum in the <em>JAK2 V617F</em> allelic burden in the ET &amp; PV patients which followed a predictable trend and was associated with increasingly complicated vascular events.</p> Bakhtiyar Alam Syed Krishna H. Goyani Shalin Vaniawala Harsh Parekh Arpan Acharya Pratap N. Mukhopadhyaya ##submission.copyrightStatement## 2019-12-27 2019-12-27 1 16