Non-Surgical Treatment Modalities in Colorectal Cancer Management: The Oncology Perspective

Silpa Choday *

Creighton University School of Health Science, Department of Internal Medicine, AZ, USA.

Tim Yu

Creighton University School of Health Science, Department of Internal Medicine, AZ, USA.

Anthony Yeung

Creighton University School of Health Science, Department of Internal Medicine, AZ, USA.

Varun Vankeshwaram

RWJBH Community medical center, Toms River, USA.

*Author to whom correspondence should be addressed.


Abstract

Colorectal cancer (CRC) is the third most common cancer worldwide, remains a major cause of cancer-related morbidity and mortality globally. It has diverse treatment modalities including chemotherapy, immunotherapy, and targeted therapies. Chemotherapy remains a cornerstone of CRC management, either as adjuvant therapy post-surgery or as palliative treatment for advanced disease. Recent advancements in immunotherapy have transformed treatments particularly in subsets characterized by microsatellite instability-high (MSI-H) or deficient DNA mismatch repair (dMMR).  Targeted therapies have revolutionized the management of CRC by specifically targeting molecular pathways involved in tumor growth and progression. This review provides a comprehensive overview of current guidelines and emerging strategies in CRC non-surgical treatment, focusing on chemotherapy regimens, immune checkpoint inhibitors (ICIs), targeted therapies, biomarkers for treatment selection, and ongoing challenges.

Keywords: Colorectal cancer, CRC, Chemotherapy, treatment, oncology, immunotherapy


How to Cite

Choday, Silpa, Tim Yu, Anthony Yeung, and Varun Vankeshwaram. 2024. “Non-Surgical Treatment Modalities in Colorectal Cancer Management: The Oncology Perspective”. International Research Journal of Oncology 7 (2):211-19. https://journalirjo.com/index.php/IRJO/article/view/161.

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