The Effect of Immunosuppression on Kaposi Sarcoma: A Case Series

Rita Nkiru Ajirenike *

Rivers State University Teaching Hospital, Nigeria.

Amaewhule Mary Nnneda

Rivers State University Teaching Hospital, Nigeria.

Dasetima D. Altraide

University of Port Harcourt Teaching Hospital, Nigeria.

Figilo Ibeinmo Moses

Federal Medical Centre, Yenagoa, Bayelsa State, Nigeria.

Amadi Ekechi Stella

Rivers State University Teaching Hospital, Nigeria.

Johnson Mine

Rivers State University Teaching Hospital, Nigeria.

Ogbu Christian.

Rivers State University Teaching Hospital, Nigeria.

*Author to whom correspondence should be addressed.


Abstract

Kaposi sarcoma (K.S) is a rare type of cancer with four clinical variants which has a link to Human Herpes Virus (HHV-8) in the etiology. Commonly seen are the acquired immunodeficiency syndrome (AIDS) -related variants. Kaposi Sarcoma occurring after solid-organ transplant is a cause of public health concern as immunosuppressive medications especially the Calcineurin inhibitors play a key role in the development of Kaposi Sarcoma after organ transplantation.

In this series, six patients with Kaposi Sarcoma were presented. Four patients had retro-viral disease; sero-positive to HIV 1 & 2 who were not compliant with their Highly Active Retro-viral Therapy (HAART), a male patient with post-transport K.S, and a case of suspected classic K.S.

In patients with Kaposi Sarcoma, early detection and switching Transplant recipient on Calcineurin inhibitors to mTOR inhibitors are basic parameters for successful management.

Keywords: Kaposi Sarcoma, Retroviral disease (RVD), renal transplantation, Calcineurin inhibitors, mTOR inhibitors


How to Cite

Ajirenike, Rita Nkiru, Amaewhule Mary Nnneda, Dasetima D. Altraide, Figilo Ibeinmo Moses, Amadi Ekechi Stella, Johnson Mine, and Ogbu Christian. 2024. “The Effect of Immunosuppression on Kaposi Sarcoma: A Case Series”. International Research Journal of Oncology 7 (2):233-38. https://journalirjo.com/index.php/IRJO/article/view/163.

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