Analysis of the Influence of Age, Size, and Gender on the Relationship Reporting and Data System (ACR TI-RADS) and the Incidence of Thyroid Cancer in Surakarta between Ultrasonography Classified by American College of Radiology Thyroid Imaging
International Research Journal of Oncology,
Background: The study aims to see if the age, tumor size and gender factors affect TI-RADS sensitivity. Ultrasonography examination (USG) plays a major role in the initial diagnosis process of a suspected thyroid tumor or cancer to evaluate thyroid nodules. ACR TI-RADS is a classification created with the aim of adapting the BI-RADS concept for thyroid pathology. Several studies have shown a positive correlation between ultrasound results and TI-RADS while on the opposite, several studies have shown decreased sensitivity and specificity of TI-RADS ultrasound classification with respect to increasing age groups. Study on the effect of age on USG and TI-RADS classification has an important role for the improvement of diagnostic procedure.
Objective: To find out whether age, size and gender has an effect on the sensitivity and specificity of USG diagnostics with the TI-RADS classification on the incidence of thyroid cancer in the Surakarta area.
Methods: This study is an analytical observational study with a retrospective design, with the sample population in the form of all results of thyroid ultrasound examination of thyroid cancer patients were carried out at Two General Hospitals in Surakarta to obtain the n=114 of research subjects who match the inclusion criteria and do not match within the predetermined exclusion criteria.
Results: The results of statistical tests carried out on several variables, namely age, gender, and tumor size on the sensitivity and specificity of TI-RADS showed mixed results. After comparing the sensitivity between groups, we used a cutoff point of 55 years and when we compared two groups of patients ( >55 vs ≤55 years old) , we found no statistically significant difference (p=0.496). In the comparison of the sensitivity to the gender variable, which was divided into two groups, the male patient group, and the female patient group with a p-value of 1.000. For comparison of the sensitivity of the size variable, grouped into two categories, patients with small-sized tumor ≤ 1 cm and those with large-sized tumor > 1 cm, a p-value of 0.160 was obtained (Table 10). The p-value for the comparison of specificity of the age variable was 0.062, of the gender variable 1.000, and he size variable 0.208 (Table 11).
Overall, it can be interpreted that the TI-RADS ultrasound examination on some variables above did not show a significant difference (validity) in sensitivity and specificity (p-value > 0.05).
Conclusion: Age, size and gender does not affect the sensitivity and specificity of USG diagnostics with the TI-RADS classification in thyroid cancer patients at Two General Hospital in Surakarta.
- Ultrasonography (USG)
- thyroid cancer.
How to Cite
Polat YD, Öztürk VS, Ersoz N, Anık A, & Karaman CZ. Is thyroid imaging reporting and data system useful as an adult ultrasonographic malignancy risk stratification method in pediatric thyroid nodules? J Med Ultrasound. 2019;27:141-5.
Dahlan MS, Penelitian Diagnostik: Dasar-dasar Teoritis dan Aplikasi dengan Program SPSS dan Stata (Diagnostic Research: Theoretical Basics and Applications with SPSS and Stata), Salemba Medika, Jakarta; 2009.
Haymart MR, Banerjee M, Norton EC. Thyroid Ultrasound & the Increase in Diagnosis of Low-risk Thyroid Cancer. J Clin Endocrinol Metab. 2019;104(3):785-792.
Juha Eun, Gyuna Dong, Hwan-baek Jung, Yongsung Jin, Kim Ji-Hoon, Kang So-Young. US Fine-Needle Aspiration Biopsy for Thyroid Malignancy: Diagnostic Performance of Seven Society Guidelines Applied to 2000 Thyroid Nodules. Radiology. 2018;287.
Huang LY, Lee YL, Chou P, Chiu W, Chu D. Thyroid Fine-Needle Aspiration Biopsy and Thyroid Cancer Diagnosis: A Nationwide Population-Based Study. PLoS ONE. 2015;10(5):e0127354.
Netter, Frank H. Thyroid Gland. Atlas of Human Anatomy 25th Edition. Jakarta: EGC; 2014.
Ramundo V, Lamartina L, Falcone R, Ciotti L, Lomonaco C, Biffoni M. Is thyroid nodule location associated with malignancy risk?. Ultrasonography. 2019;38(3):231-235.
Remonti LR, Kramer CK, Leitao CB, Pinto LC, Gross JL. Thyroid ultrasound features and risk of carcinoma: A systematic review and meta-analysis of observational studies. THYROID. 2015;25(5).
Smith PW, Hanks LR, Salomone LJ, Hanks JB. Thyroid. In: Townsend C M, Beauchamp R, Evers B M, Mattox K L. Sabiston Textbook of Surgery. Twentieth Edition. Elsevier, Philadelphia. 2016;881-922.
Sánchez JF. TI-RADS classification of thyroid nodules based on a score modified according to ultrasound criteria for malignancy. Rev. Argent. Radiol. 2014;78(3):138-148.
Shin JH, Baek JH. Ultrasonography Diagnosis and Imaging-Based Management of Thyroid Nodules: Revised Korean Society of Thyroid Radiology Consensus Statement and Recommendations. Korean J Radiol. 2016;17(3):370-395.
Tamhane S, Gharib H. Thyroid nodule update on diagnosis and Management. Clin Diabetes and Endocrinology. 2016,2017;2:17.
Biermann M. Thyroid Ultrasound Classification System Accurately Predicts Risk of Malignancy in Subcentimeter Nodules. Clin Thyroidol. 2018;30:273–276.
Dural CA, Sahbaz NA, Akarsu C, Akbulut S, Turkay R, Baytekin HF, Alis H. Feasibility of thyroid imaging reporting and data system classification in predicting thyroid malignancy. The American Surgeon. 2019;85(12):1345-1349.
Kwong N, Medici M, Angell TE, Liu X, Marqusee E, Cibas ES, et al. The Influence of Patient Age on Thyroid Nodule Formation, Multinodularity, and Thyroid Cancer Risk. J Clin Endocrinol Metab. 2015;100:4434-4440.
Russ G, Bonnema SJ, Erdogan MF, Durante C, Ngu R, Leenhardt L. European thyroid association guidelines for ultrasound malignancy risk stratification of thyroid nodules in Adults: The EU-TI-RADS Eur Thyroid J. 2017;6:225-237.
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