International Research Journal of Oncology https://journalirjo.com/index.php/IRJO <p style="text-align: justify;"><strong>International Research Journal of Oncology</strong>&nbsp;aims to publish case reports related to all aspects of oncology.&nbsp;The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.&nbsp;</p> International Research Journal of Oncology en-US International Research Journal of Oncology Epidemiology of Cancer of the Cervix in Rivers State, Niger Delta https://journalirjo.com/index.php/IRJO/article/view/30131 <p>The epidemiology of cancer of the cervix refers to the scientific study of the spread and control of the disease. In the Niger Delta region in Nigeria, cervical cancer presents as a public health concern among women in their prime age. This cancer of the uterine cervix is usually followed by a long phase of pre-invasive disease that lasts for about 10-15 years. It is characterized by a spectrum of events which progresses from cellular-dysplasia to invasive cervical cancer. It is the second most common cancer among women and one of the leading causes of cancer deaths among women not only in Niger Delta Region, but worldwide. Its incidence rate is approximately 25 per 100,000 women. If we were to conduct a one-time screening over one year, 8000 new invasive cervical cancers would be detected. Basic and epidemiologic research conducted during the past 15-20 years has provided overwhelming evidence regarding the etiologic role of infection by the human papilloma virus (HPV) as the primary cause of cervical cancer. The relative risks of cervical cancer following HPV infection as ascertained in case-control and cohort studies are among the highest in cancer epidemiology. Virtually all cervical carcinoma specimens contain HPV DNA, which suggests that HPV infection is a related cause of cervical neoplasia. Therefore, detailed knowledge of cervical cancer will help reduce its occurrence in an undeveloped region such as Niger Delta, Nigeria.</p> Azuonwu, Goodluck Timothy, Theresa E. ##submission.copyrightStatement## 2020-07-25 2020-07-25 1 12 Synergistic Effect of 5-Fluorouracil Combined with Naringin in MDA-MB-231 Human Breast Cancer Cells https://journalirjo.com/index.php/IRJO/article/view/30132 <p>Antimetabolite established as a successful therapeutics for advanced-stage breast cancers, but has recurrently shown to exhibit major side effects, which restrict drug therapy interventions. The most widely used chemotherapeutic agent is 5-Fluorouracil, however the recent report suggests that its antineoplastic activity is limited due to drug resistance developed by the cancer cells. The resistance results in the decrease in efficacy of 5-FU to improve either invasive disease-free survival or overall survival. In order to enhance 5-Fluorouracil mediated cytotoxicity, we have attempted the combination of the natural compound Naringin with 5-Fluorouracil. The combination of 5-Fluorouracil and Naringin inhibited the proliferation of MDA-MB-231 breast cancer cells determined using MTT assay. Importantly, combined treatment showed synergistic enhancement of breast cancer cell cytotoxicity. We next confirmed the cytotoxicity profile of the combination 5-Fluorouracil and Naringin in MDA-MB-231 breast cancer cells with trypan blue-based cell viability assay and determined that the IC<sub>50</sub> value is 80 μM. When 5-Fluorouuracil and Naringin incubated there is a 7–10-fold increase in cytotoxic effect on breast cancer cells. These results demonstrates that application of naringin as an adjuvant treatment during 5-Fluorouracil administration might enhance the chemotherapeutic efficacy of 5-Fluorouracil.</p> Thangavel Muthusamy L. Roshini Yadav Satish Ramalingam Ilangovan Ramachandran ##submission.copyrightStatement## 2020-07-31 2020-07-31 13 27