International Research Journal of Oncology <p style="text-align: justify;"><strong>International Research Journal of Oncology</strong>&nbsp;aims to publish case reports related to all aspects of oncology.&nbsp;The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.&nbsp;</p> International Research Journal of Oncology en-US International Research Journal of Oncology Lung Cancer with COVID-19: Symptom and Imaging Analysis-A Dilemma of Managing Multiple Comorbidities <p>According to the World Health organization worldwide Covid -19 related infection is 500 million with 6 million deaths. However, Covid-19 cases and deaths has continued to decline since the end of March 2022, a 24% and 12% decline respectively [1]. The most common symptoms of COVID-19 patients are coughs, colds, fevers, flu-like symptoms, and severe pneumonia [2]. In addition, our patient presented with complications from his Co-morbidities, such as diabetes leading to diabetic foot and emphysematous osteomyelitis. The patient was diagnosed as COVID-Positive during his regular follow-up. Meanwhile, the patient developed respiratory symptoms with CT scan findings of presumptive lung cancer. It was a diagnostic dilemma to treat the current infections or treat the patient as having severe COVID-19 pneumonia. However, continuing antibiotics and planning for further workup on lung cancer were helpful in our case. Our follow-up parameters have monitored arterial blood gas, calcitonin level, and other inflammatory markers to exclude COVID-related causes. We present this case to establish the best possible treatment plan for symptomatic COVID patients with other extreme co-morbidities and respiratory symptoms.</p> Tutul Chowdhury Uma Datta Gupta Padmaja Deb Roy Urmi Das Prasenjit Sarker Khondokar N. Hassan ##submission.copyrightStatement## 2022-05-02 2022-05-02 1 7 Linac Based Stereotactic Radiosurgery as Salvage Treatment in Primary Central nervous System Lymphoma- a Case Report <p>Primary central nervous system lymphoma (PCNSL) is&nbsp;a rare form of extranodal non-hodgkin lymphoma that is confined to the central nervous system. The treatment includes induction chemotherapy followed by whole brain radiation. However, the prognosis is dismal and residual or refractory disease is very common with not many options available to treat such cases. Stereo-tactic radiosurgery (SRS) is evolving to salvage small volume tumors in younger age and good performance status patients. With the limited facility and experience of linac based or Gamma knife SRS, there are sparse reports for such cases from the Indian sub-continent. We report our first case from our institution treated by linac based SRS in a case of refractory PCNSL.</p> Manishi Bansal Ankush Jindal Anupam Jindal Palanisamy Mohandass Saloni Rani Kumar Adhish Beri ##submission.copyrightStatement## 2022-05-12 2022-05-12 8 11 The Effect of Molecular Markers in the Treatment of Advanced Breast Cancer <p>Molecular markers may have an effect in the treatment of advanced breast cancers. Our aim is to review and analyze the studies on this subject and to reveal the effect of molecular markers in the treatment of breast cancer. In this review, current studies using molecular markers in the treatment and prognosis of advanced breast cancer were compiled, and the results were briefly discussed. Molecular markers have had a great impact on the prognosis and treatment of advanced breast cancers. In these cases, it has been shown that overall survival and prognosis-free survival are prolonged by molecular markers.</p> Hasan Acar Osman Özpar ##submission.copyrightStatement## 2022-06-06 2022-06-06 12 17 Prevalence and Outcome of Total Abdominal Hysterectomy Performed for Cervical Intraepithelial Neoplasia in Benin City <p><strong>Background:</strong> Cervical cancer is the commonest malignancy of the female genital tract in developing countries. A preventable disease with a precursor; cervical intraepithelial neoplasia (CIN), is detected by screening methods and it is treated by the use of ablative or excisional methods. Nonetheless, the incidence and death from cervical cancer have continued to rise in developing countries due to a lack of screening programs/follow up.</p> <p><strong>Aims: </strong>The study looked at the recourse to total abdominal hysterectomy (TAH) with CIN as the primary indication at the University of Benin Teaching Hospital as well as the outcome of surgery and observed complications.</p> <p><strong>Methodology:</strong> This was a 4-year retrospective cross-sectional, analytical study that was conducted on 145 women who underwent TAH for benign gynaecological conditions. Relevant data were extracted from case notes and hospital records. Analysis was performed using SPSS version 22.</p> <p><strong>Results:</strong> A total of 145 cases were analysed and the prevalence of TAH for CIN (n = 25) was 17.2%. Uterine fibroids contributed the highest prevalence for TAH at 51% followed by endometrial hyperplasia at 22.8%. The mean age distribution was 47.2 years and 96.6% were parous. The commonest adverse surgical outcome was haemorrhage, followed by a prolonged hospital stay.</p> <p><strong>Conclusion:</strong> Hysterectomy remains the most effective treatment for CIN. With the advent of effective ablative and excision procedures, it is considered overkill in developed countries. However, the lack of skills and equipment for these procedures and loss of follow-up in developing countries make hysterectomy a viable treatment modality for CIN.</p> Kehinde Osazee Emmanuel Chukwunyere Anyanwu Peter Waibode Alabrah ##submission.copyrightStatement## 2022-06-10 2022-06-10 18 25