Open Access Short Communication

Health Education as a Tool for the Prevention of Prostate Cancer in the Elderly: Experience Report

Dayara de Nazaré Rosa de Carvalho, Dandara de Fátima Ribeiro Bendelaque, Viviane Ferraz Ferreira de Aguiar, Sara Melissa Lago Sousa, Celice Ruanda Oliveira Sobrinho, Lorena Nayara Alves Neves, Carla Sena Cunha, Ivone de Melo Sousa, Nancy de Souza Felipe de Nazaré, Suzanne Lourdes Souza Carvalho, Rafael Everton Assunção Ribeiro da Costa, Ivonete Vieira Pereira Peixoto

International Research Journal of Oncology, Page 20-26

Objective: Report the realization of a health education action aimed at the prevention of prostate cancer.

Methodology: This is a descriptive study, with a qualitative approach, of the experience report type, carried out in a Municipal Health Unit (UMS). The activity took place in three main moments: Lecture; Conversation round and application of active methodologies. From the IRAMUTEQ, a textual corpus was submitted to similarity analysis.

Results: The results show that the participants do not have habits that benefit their health, such as inadequate diet and lack of physical activities, in addition to low adherence to detection tests and demand for health services. They had insufficient knowledge about the neoplasm, pointing out family history as the main risk factor for prostate cancer.

Conclusion: It is noted that the elderly has difficulties in adhering to conducts that help prevent prostate cancer, requiring the promotion of actions that provide information related to the benefits of healthy habits and the performance of tests to detect the pathology.

Open Access Original Research Article

Brain Re-irradiation for Recurrent Glioblastoma …. Is It Justified?

Waleed N. Abozeed, Shimaa E. Attia, Mohamed S. Zahi

International Research Journal of Oncology, Page 1-8

Background: Glioblastoma Multiforme (GBM) is a grade IV brain tumour with high recurrence rate despite maximum treatment including surgical resection, concurrent chemo-radiotherapy and adjuvant chemotherapy. In recurrent tumours, there is no standard treatment available.

Patients and Methods: This is a retrospective analysis of patients with recurrent GBM who presented to our department in the period between Jan 2017 to Dec 2018 and received re-irradiation after tumour recurrence. Data were collected from patient medical records to assess DFS, OAS and toxicity.

Results: Totally, 33 patients were enrolled. All cases were re-irradiated to a total dose of 30 Gy in 15 fractions. The overall survival and progression-free survival were significantly better in younger patients with good performance status and small tumour size. Only 2 cases (6.1%) developed deterioration of neurological symptoms.

Conclusion: Brain re-irradiation is a feasible and safe treatment option in patients with recurrent GBM.

Open Access Original Research Article

In vivo Effects of CortiNon+ on the Emergence and Progression of Experimental Graffi Tumor in Hamsters

Reneta Toshkova, Ignat Ignatov, Elisaveta Zvetkova, Georgi Gluhchev, Georgi Dinkov

International Research Journal of Oncology, Page 27-36

Results from a three arms pilot study on the preventive and therapeutic effects of the food supplement CortiNon+ on the development of Graffi myeloid tumor in hamsters have been presented. Biometric parameters of tumor growth and peripheral blood count were evaluated. Two schemes of experimental oral formulation of antitumor therapy were applied ne started 7 days before tumor transplantation and a second one that started simultaneously with the tumor transplantation. The control 3rd group did not receive any oral supplementations. The results demonstrated protective antitumor effect of CortiNon+, expressed by decrease of transplantability and lowering lethality, inhibition of tumor growth and increase of survival rate of the treated animals compared to the untreated ones. The efficacy of the experimental therapy was more pronounced when it was started 7 days before transplantation of the tumour cells. Also, differences in hematological parameters were registered between the groups. Presented results suggest that CortiNon+ is a promising drug candidate for treatment of haematological malignancies

Open Access Review Article

Combination of Stereotactic Radiosurgery with Immunotherapy: Is It a New Treatment Option for Brain Metastases?

Ahmet Kucuk, Erkan Topkan, Esma Didem Ikiz, Nulifer Kılıc Durankus, Sukran Senyurek, Eyub Yasar Akdemir, Duygu Sezen, Yasemin Bolukbasi, Ugur Selek, Berrin Pehlivan

International Research Journal of Oncology, Page 9-19

Brain metastases (BMs) represent the commonest intracranial tumours which occur approximately 30% of all adult patients presenting with solid cancers. The BMs do not only reduce the survival expectations but negatively alter the quality of life measures as well. For decades, surgery and whole-brain radiotherapy (WBRT) constituted the traditional treatment options with limited efficacy for the BMs. However, the unsatisfactory local control and ultimate survival outcomes led to a paradigm change, and stereotactic radiosurgery (SRS) has been executed as an alternative to surgery and WBRT or to augment the outcomes of each treatment when used in conjunction with them. In spite of the impressive improvements in the local control rates, yet the desired survival results were not achieved with SRS mainly due to the deaths ascribed to the extracranial systemic disease progression or unavoidably fatal distant brain recurrences. In this regard, as of late, numerous immunotherapeutics have been shown to improve the outcomes of various cancers, such as the locally advanced non-small-cell lung cancers. Recognizing the fact that the immunotherapy is becoming one of the indispensable components of standard treatment protocols for many tumour primaries, this review aimed to evaluate the efficacy and safety of the use of novel immunotherapeutics with standard SRS for BMs.

Open Access Review Article

Radiosurgical Management of Brainstem Metastasis

Erkan Topkan, Ahmet Kucuk, Nulifer Kilic Durankus, Sukran Senyurek, Eyub Yasar Akdemir, Duygu Sezen, Esma Didem Ikiz, Yasemin Bolukbasi, Berrin Pehlivan, Ugur Selek

International Research Journal of Oncology, Page 37-46

Brainstem metastases account only for 3% to 5% of all intracranial metastasis. However, brainstem metastases undoubtedly represent a significant source of severe morbidity and mortality in affected patients with estimated average survival duration of only less than 6 months. Surgical resection is not suitable for most brainstem metastases due to the vital architectural structure of the brainstem. What’s more, most conventional chemotherapeutics and targeted agents are ineffective on account of their low blood-brain-barrier penetration capacities. Accordingly, palliative short-course whole-brain radiotherapy stays to be the present standard of care for brainstem metastases. Nonetheless, the limited efficacy of WBRT and related neurocognitive toxicity concerns prompted eagerness on the utilization of stereotactic radiosurgery for brainstem metastases in like manner the cerebral and cerebellar metastases. In a shortage of reliable large series outcomes, the present review article meant to succinctly summarize the current stereotactic radiosurgery evidence on brainstem metastases with an explicit accentuation on the feasibility and efficacy of this novel sophisticated radiotherapy technique in such patients’ groups of bleak prognoses.