Open Access Case Study

Naso-Pharynx Muco-Squamous Cell Carcinoma: About a Case

A. Raihane, Y. Oukessou, S. Rouadi, R. Abada, M. Roubal, M. Mahtar

International Research Journal of Oncology, Page 1-5

Muco-squamous cell carcinoma is a rarely localized tumour in the cavum. Its therapeutic characteristics and prognostic factors remain unclear given the limited number of cases reported in the literature. The purpose of our work is to study the clinical, therapeutic and prognostic particuliarities of this entity.

We report the case of a patient aged 59 years, who consulted for a symptomatology made of headache, epistaxis, decrease of the visual acuity of the right eye with association of otological signs. Nasal endoscopy revealed budding formation of the cavum roof and cervical examination did not objectify lymphadenopathy. The scanner imaging showed a tissue process of the roof and posterior wall of the cavum measuring 58 mm 59 mm 47 mm, with extension to the infra temporal pit and invasion of the skull base. The biopsy of the cavum concluded to muco-squamous cell carcinoma. After extension assessment, the tumor was classified T4BN2M0. The patient was treated with exclusive radiotherapy with no local progression or remote metastases after 12 months of regression.

Open Access Original Research Article

Assessment of Carcinogenic and Non-Carcinogenic Health Risk of Some Marketed Herbal Oils in Port Harcourt, Nigeria

Imomoemi N. Thompson, Eberien-Agana S. Bartimeaus, Edna O. Nwachuku, Holy Brown, Eni-Yimini S. Agoro

International Research Journal of Oncology, Page 6-11

Aim: The aim of this study was to assess the heavy metals, carcinogenic and non-carcinogenic health risk of three marketed herbal oils in Port Harcourt.

Study Design: A cross-sectional observational study.

Place and Duration of Study: This study was carried out at Anal Concept Limited located at 12 Poultry road, Odani Green City Elelenwo, Port Harcourt, Rivers State, Nigeria, between April 2020 and June 2020.

Methodology: The level of cadmium, lead, copper, arsenic and zinc was determined. While the carcinogenic (chronic daily intake and hazard quotient) and non-carcinogenic health risk (incremental lifetime cancer risk) were calculated. The three herbal oils were named sample A, B, and C. The oils were digested with concentrated HCL before quantification of cadmium, arsenic, lead, copper and zinc /using an atomic absorption spectrophotometer. Then the carcinogenic and non- carcinogenic health risk of each cosmetic were calculated.

Results: The results indicated that the concentrations of lead, cadmium and arsenic exceeded the maximum allowable concentrations, whereas zinc and copper is found below the acceptable limit set by WHO/EU in cosmetic A, B and C with sample A>C>B. The chronic daily intake (CDI) and hazard quotient were below the allowable limit for all three cosmetics. The incremental lifetime cancer risk was above the allowable limit of normal for all three cosmetics with cosmetic A > C > B. The results indicated that there are chances of cancer resulting from the use of these cosmetic products due to the build-up of the heavy metals contained in the products.

Conclusion: The result showed that all three different cosmetic brands had cadmium and arsenic levels above the acceptable limit for cosmetic products.

Open Access Original Research Article

The Profile of Lymphocyte, Monocyte and Lymphocyte-monocyte Ratio in Colorectal Cancer Patients at Moewardi Hospital the Period from March to April 2019 (Retrospective Research)

Mia Rachmi Widyaningrum, Ida Bagus Budhi Surya Adnyana

International Research Journal of Oncology, Page 12-20

Background: Based on Globocan data (2012), the incidence of colorectal cancer in Indonesia is 12.8 per 100,000 adult population, with mortality of 9.5% of all cancer case. The ratio of neutrophil to lymphocytes, ratio of platelets to lymphocyte, C-reactive protein, and albumin are predictors in analyzing the changes that occur before and after treatment (chemotherapy and/or surgery) in patients with carcinoma.

Methods: This was a retrospective study, conducted Moewardi Hospital Surakarta during the period of March - April 2019. In that period there were 226 colorectal cancer patients admitted to the inpatient ward of the Moewardi Hospital. With the Slovin formula, we analyzed data from 70 patients as samples. The normal rate of Lymphocyte are 2% -40%, Monocyte are 2%-8%, and the normal rate of Lymphocyte to Monocyte Ratio are 2,1% – 3,8%.

Results: From the 70 patients analyzed, consisting of 40 male patients (57,1%) and 30 women (42,9%). Based on age distribution, 9%  were 31-40 years old, 10% were 41-50 years old, 37% were 51-60 years old, 13% were 61-70 years old, and 4% were over 70 years old. 52.8% of patients showed a decrease in monocyte count, while the remaining 47.2% were normal.  21.4% of patiens increased lymphocyte count, 15.7% of patients decreased lymphocyte count, while 48.6% were normal. From the 70 patients analyzed, 37,1% increased rates of Lymphocyte Monocytes Ratio, 44,3% normal and 13,5% showed a decrease in Lymphocyte-Monocyte Ratio.

Conclusion: In a retrospective study of 70 paents of colorectal cancer showed significant results that  44,3%  patients have a normal Lymphocyte-Monocyte Ratio (LMR). Based on gender, it is more affected by men than women with a ratio of 4: 3. The most age distribution is at the age of 51-60 years and the rarest at the age above 70 years. Half of the patients studied showed an increase in lymphocyte count, and only a small proportion had a decreased lymphocyte count.

Open Access Original Research Article

Clinicopathological Factors Predicting Survival in Women with Advanced Ovarian Cancer Treated with NACT Followed by IDS - A Retrospective Study

Megha Nandwani, Sharda Patra, Debabrata Barmon, Upasana Baruah, Roma Jethani

International Research Journal of Oncology, Page 21-28

Introduction: Ovarian cancer is mostly diagnosed at an advanced stage due to its initial asymptomatic nature. It is often associated with high morbidity and mortality. Neo-adjuvant chemotherapy followed by interval debulking surgery is the primary modality of treatment accepted now a days. Our study was conducted in these cases and predictors of survival evaluated.

Aims: To study the clinicopathological factors predicting outcome survival in women with advanced ovarian cancer treated with neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS).

Methods: A retrospective observational study was conducted over a period of two years from 1st January 2014 to 31st December 2015. All patients with serous epithelial ovarian tumors who received NACT (neo-adjuvant chemotherapy); 3 to 4 cycles followed by IDS (interval debulking surgery) followed by 3 cycles of adjuvant chemotherapy were studied. Factors influencing their overall survival were critically analyzed and evaluated.

Results: A retrospective study was conducted from 1st January 2014 to 31st December 2015; a total of 50 patients with carcinoma ovary were studied. All the patients belonged to stage III and above with a mean age of 46.16 years. All the patients had histopathology report of epithelial serous ovarian carcinoma and all the fifty patients received NACT followed by IDS and then adjuvant chemotherapy. At the end of 5 years, 24% patients were alive and 76% patients expired. The total recurrences in the study population was 86%. The mean overall survival at the end of 5 years was 15.2%. Absence of ascites post neo-adjuvant chemotherapy was a significant predictor of 5 year survival (p<0.0001). Type of resection, maximum tumor burden site and CA125 levels were also contributory prognostic factors in these patients.

Conclusion: The predictors of survival based on clinicopathological response to neoadjuvant chemotherapy after interval debulking surgery in advanced epithelial ovarian carcinoma include absence of ascites post NACT, R0 type of resection, maximum tumor burden at ovary or colon and post treatment mean CA125 levels of 33.97.

Open Access Original Research Article

A Study of Involvement of Nipple Areola Complex in Carcinoma Breast to Devise an Algorithm for its Preservation

Anupam Lahiri, Ashwini Kumar Malhotra

International Research Journal of Oncology, Page 29-39

Aim: This study is conducted to assess the involvement of nipple-areola complex in patients of carcinoma breast who are undergoing mastectomy, to develop criteria to preserve the nipple-areola complex. Thiswould prevent its unnecessary removalwhile promoting its preservation.

Materials and Methods: This prospective study has been carried out in the Department of General Surgery, in SOUTH EASTERN RAILWAY HOSPITAL, KOLKATA, India, between November 2018 to October  2020.The histopathological reports were studied to derive factors predisposing to nipple-areola complex involvement.

Results: Analysis reveals that patients with tumors in multiple quadrants, subareolar location, multifocal or multicentric tumors, large size, advanced grade, Her-2-neu positive with significant lymph nodes, and tumors in the vicinity of the nipple-areola complex are poor candidates for nipple-areola sparing mastectomy.The analysis also reveals that age, BMI, parity, side of breast involved or ER and PR status do not have any bearing on Nipple areola sparing mastectomy.

Conclusion: Nipple areola sparing mastectomy is a viable option in carcinoma breast patients undergoing curative surgery.